The medium to be distilled is an intermediate from the synthesis of an anti-cancer drug. The powder drying process was allowed to last a maximum of 8 hours. During this time, the temperature of the sensitive medium was not allowed to rise above 35 ° C. During drying, no lumps were allowed to form in the flask. The residual moisture of the medium should be as low as possible.
The setup consisted of the Hei-VAP Industrial with the glassware A1 and the 20 liter powder flask, in combination with the Automatic Module - Distimatic. Furthermore, the Rotavac 20 vacuum pump and the Hei-CHILL 5000 recirculating cooler were used. The heating bath was automatically supplied with water and automatically refilled if necessary.
First, 0.5 kg of a fluid amide-like derivative in powder form was dissolved in 10 liters of IPA (isopropanol) in the 20-liter flask of a Hei-VAP Industrial and mixed for 5 minutes at 100 rpm and 25 ° C. The flask was removed from the evaporator and 0.5 kg of calcium sulfate was added manually to the mixture. As a result, the color changed to beige. Thereafter, the distillation was started. Distillation parameters were set on:
After 4 hours of distillation, the powder drying was completed. All requirements of the application were successfully met.
The solution of IPA and the medium After the addition of the calcium sulfate The finished dried product
with glassware A1
Highest safety and integrated
vacuum control capabilities
Powder flask 20 l
Without automatic drainage of
Includes secondary condenser
and air intake separation vessel
Comprehensive spectrum of
services for demanding
temperature control tasks with a
cooling capacity of 5,000 W.
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